JFNAX

Active

Janus Henderson Global Life Sciences Fund

Category: US Equity (9,528 funds)

Expense Ratio

0.98%

Annual Cost per $10K

$98.00

30-Year Fee Drag per $10K

$18,362

at 7% annual return

Fund Type

Mutual Fund

Active

Trailing 12-Month

-3.65%

Asset Allocation

US Equity

81%

Intl Equity

10%

Other

Fee Comparison

JFNAX

0.98%

US Equity average

1.06%

US Equity cheapest

BKLC

0.00%

Index benchmark

0.03%

8% cheaper than category average

Historical Returns

Monthly total returns (dividends reinvested) from SEC N-PORT filings · As of December 2025 · Updated quarterly

+33.94%3Y

Compare to

Fee Impact Calculator

Investment

Years

Annual Return

JFNAX at 0.98%$288,805

At index rates (0.03%)$377,424

Zero fees (theoretical)$380,613

Total fee drag$91,808

Cost vs index fund−$88,620

Similar Funds (100)

Ranked by allocation similarity weighted by fund size · Returns (dividends reinvested) from SEC N-PORT filings · As of December 2025

Ticker	Name	ER	1yr	3yr	5yr
JFNAX	Janus Henderson Global Life Sciences Fund	0.98%	-3.65%	+10.23%	+5.56%
AICCX	Investment Co of America	0.32%	+19.77%	+23.76%	+16.99%
AFMFX	American Mutual Fund	0.57%	+13.05%	+13.96%	+14.17%
DODGX	Dodge & Cox Stock Fund$1M min	0.51%	+11.41%	+15.46%	+17.97%
MEIAX	MFS Value Fund	0.79%	+6.16%	+11.44%	+11.43%
AAGTX	American Funds 2040 Target Date Retirement Fund	0.68%	+18.44%	+18.13%	+12.03%
PMBJX	MidCap Fund	0.80%	+2.44%	+15.49%	+11.53%
PEIYX	Putnam Large Cap Value Fund	0.63%	+13.21%	+17.09%	+15.02%
CGPAX	American Funds Growth Portfolio	0.99%	+22.86%	+23.13%	+13.61%
TRUZX	T. Rowe Price New Horizons Fund, Inc.	0.64%	+0.52%	+6.83%	+0.92%
FOCKX	Fidelity OTC Portfolio	1.05%	+32.05%	+32.26%	+18.50%
RPMGX	T. Rowe Price Mid-Cap Growth Fund, Inc.	0.75%	+4.04%	+11.09%	+7.07%
TRMIX	T. Rowe Price Mid-Cap Value Fund, Inc.	0.71%	+4.94%	+14.34%	+15.79%
AALTX	American Funds 2050 Target Date Retirement Fund	0.69%	+19.54%	+19.11%	+12.43%
FFOJX	Select Technology Portfolio	0.91%	—	—	—
MCPRX	MFS Mid Cap Growth Fund	1.02%	+12.23%	+13.48%	+6.85%
FZANX	Fidelity Advisor New Insights Fund	0.53%	+27.28%	+30.87%	+17.96%
FRDPX	Franklin Rising Dividends Fund	0.83%	+9.76%	+12.44%	+12.30%
FKDNX	Franklin Dynatech Fund	0.82%	+25.20%	+29.11%	+11.86%
MVCKX	MFS Mid Cap Value Fund	0.62%	+3.62%	+11.45%	+13.94%
WFPRX	Allspring Special Mid Cap Value Fund	0.70%	+4.11%	+10.49%	+8.18%
BLPAX	American Funds Moderate Growth and Income Portfolio	0.93%	+15.22%	+14.72%	+9.87%
TRZDX	T. Rowe Price Dividend Growth Fund, Inc.	0.49%	+12.05%	+14.42%	—
THISX	T. Rowe Price Health Sciences Fund, Inc.	0.67%	-6.04%	+2.14%	+3.90%
TRZQX	T. Rowe Price Equity Income Fund	0.53%	+11.38%	+12.97%	—
DDFIX	Invesco Diversified Dividend Fund	1.07%	+11.24%	+11.94%	+13.20%
FIFRX	Franklin Growth Fund	0.46%	+13.95%	+19.62%	+12.70%
JMGFX	JPMorgan Mid Cap Growth Fund	1.09%	+14.48%	+15.50%	+8.63%
VAFAX	Invesco American Franchise Fund	0.93%	+20.11%	+24.09%	+11.60%
TRZZX	T. Rowe Price Small-Cap Stock Fund, Inc.	0.74%	+10.00%	+11.20%	+9.48%
PNOBX	Putnam Sustainable Leaders Fund	0.88%	+40.92%	+8.87%	+14.93%
QVG2Q	VIP Growth Portfolio	0.66%	+16.25%	+25.36%	+16.18%
FGIDX	Fidelity Growth and Income Portfolio	0.46%	—	—	—
PRWAX	T. Rowe Price All-Cap Opportunities Fund	0.79%	+18.45%	+22.46%	+15.67%
FDGFX	Fidelity Dividend Growth Fund	1.16%	+22.11%	+22.12%	+19.34%
ACCLX	Mid Cap Value Fund	0.62%	+6.54%	+7.74%	+10.84%
FZAFX	Fidelity Advisor Equity Growth Fund	0.55%	+14.23%	+21.96%	+14.29%
POAGX	PRIMECAP Odyssey Aggressive Growth Fund	0.66%	+32.05%	+22.35%	+12.25%
ACSHX	Invesco Comstock Fund	0.51%	+12.71%	+14.13%	+19.36%
POGRX	PRIMECAP Odyssey Growth Fund	0.66%	+31.82%	+22.63%	+16.61%
LCBEX	ClearBridge Dividend Strategy Fund	0.66%	+12.74%	+15.51%	+14.91%
FFDKX	Fidelity Fund	0.42%	+19.09%	+24.15%	+16.34%
FSPHX	Select Health Care Portfolio	0.63%	-7.78%	+4.19%	+3.06%
BGRUX	BARON GROWTH FUND	1.09%	-10.30%	+2.52%	+4.33%
FCAKX	Fidelity Capital Appreciation Fund	0.66%	+19.00%	+23.80%	+16.27%
FVD	First Trust Value Line Dividend Index Fund	0.61%	+5.42%	+8.35%	+10.29%
FADTX	Fidelity Advisor Technology Fund	0.55%	+9.19%	-20.09%	-33.76%
TRZVX	T. Rowe Price Small-Cap Value Fund, Inc.	0.64%	+7.01%	+8.70%	+11.40%
FHZTX	Fidelity Large Cap Stock Fund	1.02%	—	—	—
ARKK	ARK Innovation ETF	0.75%	+93.79%	+32.47%	+0.08%
GOGFX	Victory Sycamore Small Company Opportunity Fund	1.23%	+3.01%	+5.50%	+10.36%
JLVMX	JPMorgan Large Cap Value Fund	0.93%	+12.44%	+13.65%	+18.22%
XFBRX	VIP Mid Cap Portfolio	0.82%	+9.10%	+13.98%	+13.79%
FCAGX	Fidelity Small Cap Growth Fund	0.92%	-11.50%	-33.45%	-40.48%
HQIFX	THE HARTFORD EQUITY INCOME FUND	0.64%	+8.42%	+10.32%	+13.52%
POSKX	PRIMECAP Odyssey Stock Fund	0.67%	+21.63%	+19.53%	+17.10%
ACSCX	Small Cap Value Fund	0.73%	-0.02%	+6.19%	+12.90%
PARWX	Parnassus Value Equity Fund	0.88%	+14.22%	+5.02%	+3.06%
PRDSX	T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund	0.79%	+6.80%	+13.28%	+8.88%
POLRX	Polen Growth Fund	1.22%	+13.28%	+18.03%	+7.98%
FDSVX	Fidelity Growth Discovery Fund	0.62%	+16.70%	+25.53%	+16.34%
MFRJX	MFS Research Fund	0.52%	+13.48%	+17.53%	+13.88%
TMSIX	THRIVENT MID CAP STOCK FUND	0.74%	+2.81%	+8.15%	+10.43%
TRSSX	T. Rowe Price Institutional Small-Cap Stock Fund$1M min	0.66%	+9.13%	+10.31%	+8.57%
SHISX	BlackRock Health Sciences Opportunities Portfolio	1.15%	-8.85%	+5.97%	+4.29%
ISTNX	Macquarie Science and Technology Fund	1.42%	+36.24%	+34.68%	+10.73%
FCPVX	Fidelity Small Cap Value Fund	1.20%	+5.81%	+10.40%	+15.81%
MITJX	Massachusetts Investors Trust	0.38%	+14.22%	+17.54%	+14.57%
HFMVX	THE HARTFORD MIDCAP FUND	0.73%	+4.81%	+8.14%	+5.35%
MRERX	MFS Core Equity Fund	0.88%	+12.40%	+16.13%	+12.14%
AMAGX	Amana Growth Fund	0.61%	+5.41%	+16.31%	+12.67%
ACGIX	Invesco Growth and Income Fund	0.78%	+11.11%	+13.67%	+15.50%
ICEQX	Macquarie Core Equity Fund	0.74%	+16.32%	+21.38%	+8.34%
ACFLX	Focused Large Cap Value Fund	1.09%	+11.12%	+12.26%	—
LAFVX	LORD ABBETT AFFILIATED FUND INC	0.39%	+11.58%	+14.40%	+14.19%
WGROX	Wasatch Core Growth Fund	1.17%	-8.92%	+9.98%	+7.06%
LCSSX	ClearBridge Select Fund	0.98%	+15.74%	+18.42%	+9.49%
FRCSX	Franklin Small Cap Value Fund	0.60%	+5.18%	+9.64%	+12.87%
HIACX	HARTFORD CAPITAL APPRECIATION HLS FUND	0.67%	+13.11%	+17.70%	+12.83%
FMILX	Fidelity New Millennium Fund	0.76%	+18.23%	+23.09%	+20.67%
JAAGX	Janus Henderson Enterprise Portfolio$1M min	0.97%	+8.64%	+18.56%	+10.27%
NICSX	Nicholas Fund, Inc.	0.70%	+5.92%	+21.26%	+13.64%
FCDAX	Fidelity Stock Selector Small Cap Fund	0.85%	-14.07%	-34.60%	-38.61%
JLCVX	Fundamental Large Cap Core Fund	0.71%	+14.35%	+20.45%	+15.31%
FBIOX	Select Biotechnology Portfolio	0.63%	-2.61%	+9.74%	+2.99%
HIADX	HARTFORD DIVIDEND AND GROWTH HLS FUND	0.66%	+11.19%	+13.60%	+15.24%
MGRPX	GROWTH PORTFOLIO	0.52%	+62.48%	+37.76%	+7.82%
QTEC	First Trust NASDAQ-100-Technology Sector Index Fund	0.55%	+24.22%	+29.50%	+14.91%
ASPZX	ALGER SPECTRA FUND	1.19%	+49.31%	+26.32%	+15.02%
APDMX	Artisan Mid Cap Fund	1.05%	+17.84%	+14.38%	+5.25%
SGRAX	Allspring Growth Fund	1.15%	+24.78%	+26.91%	+15.34%
FACDX	Fidelity Advisor Health Care Fund	0.68%	-17.79%	-39.08%	-43.42%
LAMHX	Lord Abbett Dividend Growth Fund	0.59%	+11.84%	+17.12%	+13.38%
FVDFX	Fidelity Value Discovery Fund	0.77%	+9.04%	+8.93%	+12.48%
LADCX	LORD ABBETT DEVELOPING GROWTH FUND INC	0.94%	+18.91%	+12.68%	+3.03%
CCASX	CONESTOGA SMALL CAP FUND	1.10%	-6.78%	+5.14%	+3.68%
FGSLX	Fidelity Growth Strategies Fund	0.61%	—	—	—
PNSAX	Putnam Small Cap Growth Fund	1.17%	+16.26%	+22.02%	+8.87%
AALRX	American Beacon Large Cap Value Fund	0.62%	+9.19%	+13.80%	+16.22%
RCEYX	Victory RS Large Cap Alpha Fund	0.68%	+11.59%	+15.28%	+16.26%
ABSZX	AB Discovery Value Fund	0.81%	+4.04%	+9.57%	+13.71%

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