JFNSX

Active

Janus Henderson Global Life Sciences Fund

Category: US Equity (9,528 funds)

Expense Ratio

1.18%

Annual Cost per $10K

$118.00

30-Year Fee Drag per $10K

$21,543

at 7% annual return

Fund Type

Mutual Fund

Active

Trailing 12-Month

-3.86%

Asset Allocation

US Equity

81%

Intl Equity

10%

Other

Fee Comparison

JFNSX

1.18%

US Equity average

1.06%

US Equity cheapest

BKLC

0.00%

Index benchmark

0.03%

11% more expensive than category average

Historical Returns

Monthly total returns (dividends reinvested) from SEC N-PORT filings · As of December 2025 · Updated quarterly

+33.17%3Y

Compare to

Fee Impact Calculator

Investment

Years

Annual Return

JFNSX at 1.18%$272,899

At index rates (0.03%)$377,424

Zero fees (theoretical)$380,613

Total fee drag$107,713

Cost vs index fund−$104,525

Similar Funds (100)

Ranked by allocation similarity weighted by fund size · Returns (dividends reinvested) from SEC N-PORT filings · As of December 2025

Ticker	Name	ER	1yr	3yr	5yr
JFNSX	Janus Henderson Global Life Sciences Fund	1.18%	-3.86%	+10.02%	+5.35%
TIACX	Investment Co of America	0.63%	+20.95%	+24.94%	+18.10%
RFNAX	American Funds Fundamental Investors	1.37%	+21.05%	+22.85%	+16.25%
MEIAX	MFS Value Fund	0.79%	+6.16%	+11.44%	+11.43%
AAGTX	American Funds 2040 Target Date Retirement Fund	0.68%	+18.44%	+18.13%	+12.03%
PMBJX	MidCap Fund	0.80%	+2.44%	+15.49%	+11.53%
CGPAX	American Funds Growth Portfolio	0.99%	+22.86%	+23.13%	+13.61%
PEIYX	Putnam Large Cap Value Fund	0.63%	+13.21%	+17.09%	+15.02%
PAMCX	T. Rowe Price Mid-Cap Growth Fund, Inc.	1.01%	+3.79%	+10.80%	+6.79%
FOCKX	Fidelity OTC Portfolio	1.05%	+32.05%	+32.26%	+18.50%
TRUZX	T. Rowe Price New Horizons Fund, Inc.	0.64%	+0.52%	+6.83%	+0.92%
TADGX	T. Rowe Price Dividend Growth Fund, Inc.	0.89%	+11.08%	+13.41%	+12.98%
FRDRX	Franklin Rising Dividends Fund	1.08%	+9.52%	+12.18%	+12.02%
MCPRX	MFS Mid Cap Growth Fund	1.02%	+12.23%	+13.48%	+6.85%
FDNRX	Franklin Dynatech Fund	1.07%	+24.89%	+28.81%	+11.59%
FFOJX	Select Technology Portfolio	0.91%	—	—	—
TRMIX	T. Rowe Price Mid-Cap Value Fund, Inc.	0.71%	+4.94%	+14.34%	+15.79%
BLPAX	American Funds Moderate Growth and Income Portfolio	0.93%	+15.22%	+14.72%	+9.87%
FKGRX	Franklin Growth Fund	0.79%	+13.59%	+19.22%	+12.33%
FZANX	Fidelity Advisor New Insights Fund	0.53%	+27.28%	+30.87%	+17.96%
WFPRX	Allspring Special Mid Cap Value Fund	0.70%	+4.11%	+10.49%	+8.18%
MVCKX	MFS Mid Cap Value Fund	0.62%	+3.62%	+11.45%	+13.94%
DDFIX	Invesco Diversified Dividend Fund	1.07%	+11.24%	+11.94%	+13.20%
JMGFX	JPMorgan Mid Cap Growth Fund	1.09%	+14.48%	+15.50%	+8.63%
THISX	T. Rowe Price Health Sciences Fund, Inc.	0.67%	-6.04%	+2.14%	+3.90%
JDVFX	Disciplined Value Fund	1.71%	+14.34%	+15.14%	+17.50%
TRZQX	T. Rowe Price Equity Income Fund	0.53%	+11.38%	+12.97%	—
VAFAX	Invesco American Franchise Fund	0.93%	+20.11%	+24.09%	+11.60%
PNOBX	Putnam Sustainable Leaders Fund	0.88%	+40.92%	+8.87%	+14.93%
TRZZX	T. Rowe Price Small-Cap Stock Fund, Inc.	0.74%	+10.00%	+11.20%	+9.48%
FDGFX	Fidelity Dividend Growth Fund	1.16%	+22.11%	+22.12%	+19.34%
PAWAX	T. Rowe Price All-Cap Opportunities Fund	1.05%	+18.13%	+22.14%	+15.36%
PASVX	T. Rowe Price Small-Cap Value Fund, Inc.	1.16%	+5.76%	+7.48%	+10.17%
QVG2Q	VIP Growth Portfolio	0.66%	+16.25%	+25.36%	+16.18%
BGRUX	BARON GROWTH FUND	1.09%	-10.30%	+2.52%	+4.33%
GOGFX	Victory Sycamore Small Company Opportunity Fund	1.23%	+3.01%	+5.50%	+10.36%
ACCLX	Mid Cap Value Fund	0.62%	+6.54%	+7.74%	+10.84%
FGIDX	Fidelity Growth and Income Portfolio	0.46%	—	—	—
UBVAX	Undiscovered Managers Behavioral Value Fund	1.24%	+4.21%	+9.09%	+17.73%
FHZTX	Fidelity Large Cap Stock Fund	1.02%	—	—	—
POAGX	PRIMECAP Odyssey Aggressive Growth Fund	0.66%	+32.05%	+22.35%	+12.25%
LCBEX	ClearBridge Dividend Strategy Fund	0.66%	+12.74%	+15.51%	+14.91%
FZAFX	Fidelity Advisor Equity Growth Fund	0.55%	+14.23%	+21.96%	+14.29%
POGRX	PRIMECAP Odyssey Growth Fund	0.66%	+31.82%	+22.63%	+16.61%
FSPHX	Select Health Care Portfolio	0.63%	-7.78%	+4.19%	+3.06%
ISTNX	Macquarie Science and Technology Fund	1.42%	+36.24%	+34.68%	+10.73%
FKMCX	Fidelity Mid-Cap Stock Fund	1.69%	+10.06%	+11.41%	+14.78%
FCAKX	Fidelity Capital Appreciation Fund	0.66%	+19.00%	+23.80%	+16.27%
JLVMX	JPMorgan Large Cap Value Fund	0.93%	+12.44%	+13.65%	+18.22%
POLRX	Polen Growth Fund	1.22%	+13.28%	+18.03%	+7.98%
FCAGX	Fidelity Small Cap Growth Fund	0.92%	-11.50%	-33.45%	-40.48%
TQAAX	T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund	1.07%	+6.54%	+12.98%	+8.58%
ARKK	ARK Innovation ETF	0.75%	+93.79%	+32.47%	+0.08%
MITHX	Massachusetts Investors Trust	0.70%	+13.85%	+17.16%	+14.20%
MFRFX	MFS Research Fund	0.77%	+13.18%	+17.22%	+13.59%
FFDKX	Fidelity Fund	0.42%	+19.09%	+24.15%	+16.34%
XFBRX	VIP Mid Cap Portfolio	0.82%	+9.10%	+13.98%	+13.79%
FADTX	Fidelity Advisor Technology Fund	0.55%	+9.19%	-20.09%	-33.76%
FCPVX	Fidelity Small Cap Value Fund	1.20%	+5.81%	+10.40%	+15.81%
SHISX	BlackRock Health Sciences Opportunities Portfolio	1.15%	-8.85%	+5.97%	+4.29%
PARWX	Parnassus Value Equity Fund	0.88%	+14.22%	+5.02%	+3.06%
ACSCX	Small Cap Value Fund	0.73%	-0.02%	+6.19%	+12.90%
POSKX	PRIMECAP Odyssey Stock Fund	0.67%	+21.63%	+19.53%	+17.10%
HQIFX	THE HARTFORD EQUITY INCOME FUND	0.64%	+8.42%	+10.32%	+13.52%
WGROX	Wasatch Core Growth Fund	1.17%	-8.92%	+9.98%	+7.06%
NLSIX	Neuberger Berman Long Short Fund$1M min	1.32%	+10.16%	+9.96%	+7.15%
ACFLX	Focused Large Cap Value Fund	1.09%	+11.12%	+12.26%	—
TMSIX	THRIVENT MID CAP STOCK FUND	0.74%	+2.81%	+8.15%	+10.43%
MRERX	MFS Core Equity Fund	0.88%	+12.40%	+16.13%	+12.14%
FDSVX	Fidelity Growth Discovery Fund	0.62%	+16.70%	+25.53%	+16.34%
LAAFX	LORD ABBETT AFFILIATED FUND INC	0.54%	+11.50%	+14.25%	+14.03%
TRSSX	T. Rowe Price Institutional Small-Cap Stock Fund$1M min	0.66%	+9.13%	+10.31%	+8.57%
LCSSX	ClearBridge Select Fund	0.98%	+15.74%	+18.42%	+9.49%
HFMVX	THE HARTFORD MIDCAP FUND	0.73%	+4.81%	+8.14%	+5.35%
ACGIX	Invesco Growth and Income Fund	0.78%	+11.11%	+13.67%	+15.50%
FIAQX	Fidelity Equity Dividend Income Fund	1.08%	—	—	—
ICEQX	Macquarie Core Equity Fund	0.74%	+16.32%	+21.38%	+8.34%
AMAGX	Amana Growth Fund	0.61%	+5.41%	+16.31%	+12.67%
ASPZX	ALGER SPECTRA FUND	1.19%	+49.31%	+26.32%	+15.02%
JLCFX	Fundamental Large Cap Core Fund	0.91%	+14.14%	+20.23%	+15.08%
JAAGX	Janus Henderson Enterprise Portfolio$1M min	0.97%	+8.64%	+18.56%	+10.27%
SGRAX	Allspring Growth Fund	1.15%	+24.78%	+26.91%	+15.34%
MGHRX	GROWTH PORTFOLIO	0.73%	+62.50%	+37.70%	+7.77%
APDMX	Artisan Mid Cap Fund	1.05%	+17.84%	+14.38%	+5.25%
FMILX	Fidelity New Millennium Fund	0.76%	+18.23%	+23.09%	+20.67%
FCDAX	Fidelity Stock Selector Small Cap Fund	0.85%	-14.07%	-34.60%	-38.61%
NDVAX	MFS New Discovery Value Fund	1.46%	+2.93%	+8.47%	+13.01%
CCASX	CONESTOGA SMALL CAP FUND	1.10%	-6.78%	+5.14%	+3.68%
HIACX	HARTFORD CAPITAL APPRECIATION HLS FUND	0.67%	+13.11%	+17.70%	+12.83%
FRCSX	Franklin Small Cap Value Fund	0.60%	+5.18%	+9.64%	+12.87%
FSIUX	Invesco Dividend Income Fund	1.69%	+10.37%	+10.85%	+12.44%
NICSX	Nicholas Fund, Inc.	0.70%	+5.92%	+21.26%	+13.64%
ACLCX	Value Fund	1.45%	+10.26%	+9.86%	+13.91%
PNSAX	Putnam Small Cap Growth Fund	1.17%	+16.26%	+22.02%	+8.87%
AVPAX	American Beacon Small Cap Value Fund	1.15%	+0.85%	+7.15%	+13.44%
VVOAX	Invesco Value Opportunities Fund	1.27%	+18.64%	+20.63%	+24.43%
LADCX	LORD ABBETT DEVELOPING GROWTH FUND INC	0.94%	+18.91%	+12.68%	+3.03%
MEFAX	MassMutual Mid Cap Growth Fund	1.11%	+9.08%	+15.28%	+5.46%
FVDFX	Fidelity Value Discovery Fund	0.77%	+9.04%	+8.93%	+12.48%
HIADX	HARTFORD DIVIDEND AND GROWTH HLS FUND	0.66%	+11.19%	+13.60%	+15.24%
FACDX	Fidelity Advisor Health Care Fund	0.68%	-17.79%	-39.08%	-43.42%

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